Study: CBD May be Effective in the Treatment of Painful Diabetic Neuropathy
According to a new study being published by the journal Brain Research, and epublished online by the National Institute of Health, cannabidiol (CBD) ” may be effective in the treatment of painful diabetic neuropathy “.
“Most diabetic patients describe moderate to severe pain symptoms whose pharmacological treatment is palliative and poorly effective”, states the study’s abstract. “Cannabidiol (CBD) has shown promising results in painful conditions.” With this in mind, researchers “aimed to investigate the potential antinociceptive effect of CBD over the mechanical allodynia in streptozotocin-induced diabetic (DBT) rats, as well as its involved mechanisms.”
For the study, “Wistar adult male diabetic rats were treated acutely or sub-chronically (for 14 days) with CBD (0.1, 0.3 or 3 mg/Kg, intraperitoneal; i.p.) and had their mechanical threshold assessed using the electronic Von Frey. ” Acute treatment with CBD (at doses of 0.3 and 3 mg/Kg) “exerted a significant anti-allodynic effect, which is not associated with locomotor impairment. “The antinociceptive effect of CBD (3 mg/Kg) was not altered by the pre-treatment with CB1 or CB2 receptor antagonists (AM251 and AM630; respectively; both at a dose of 1 mg/kg, i.p.) nor by glycine receptor antagonist (strychnine hydrochloride, 10 μg/rat, intrathecal, i.t.).”
“However,” the study states,